Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: A predictor of transition to psychotic disorder?

M Föcking; P Dicker; LM Lopez; M Cannon; MR Schäfer; PD McGorry; S Smesny; DR Cotter; GP Amminger

Journal article

Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: A predictor of transition to psychotic disorder?

M Föcking, P Dicker, LM Lopez, M Cannon, MR Schäfer, PD McGorry, S Smesny, DR Cotter, GP Amminger

BMC Psychiatry | BIOMED CENTRAL LTD | Published : 2016

DOI: 10.1186/s12888-016-1039-7

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Abstract

Background: The identification of biomarkers of transition from the at-risk mental state (ARMS) to psychotic disorder is important because early treatment of psychosis is associated with improved outcome. Increasing evidence points to an inflammatory contribution to psychosis. We questioned whether raised levels of plasma inflammatory markers predict transition from ARMS to psychotic disorder and whether any such predictors could be reduced by omega-3 (ω-3) polyunsaturated fatty acids (PUFAs). Methods: We measured the levels of 40 neuroinflammation biomarkers using a commercially available immunoassay kit. Firstly, we compared inflammatory markers in subjects in the ARMS who transitioned to ..

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University of Melbourne Researchers

Patrick McGorry Author

Paul Amminger Author

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Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This study was supported by the Health Research Board (HRB, Clinician Scientist Award to D.R.C.). The work was supported by grant 03 T-315 from the Stanley Medical Research Institute. G.P.A. was supported by National Health and Medical Research Council Australia (NHMRC) Senior Research Fellowship (ID: 1080963); P.D.M. was supported by NHMRC Senior Principal Research Fellowship (ID: 1060996). The funding body had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.